Université de Genève

Neuroscience center

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Group leader: Emi Nagoshi

Group name: Behavioral neuroscience and neurodegeneration

Affiliation: Sciences

Research activities:

image How does the nervous system generate and modulate behaviors? What causes abnormal behaviors? The research in our lab is aiming at answering these questions at the molecular and neuronal levels. To this end, we have been pursuing two research foci related to locomotor behavior: 1. Molecular and neural basis of circadian locomotor behavior, and 2. Mechanisms of neurodegeneration in Parkinsonís disease. We take a multidisciplinary approach combining molecular biology, high-throughput genomic techniques, genetics, behavioral assays and live-imaging. We have been using Drosophila melanogaster as a principal model system, because its small-scale nervous system and a battery of advanced genetic tools enable the interrogation of neural circuits and molecular mechanisms in vivo. For the study of Parkinsonís disease, we are now expanding our work into the research using mouse models.

Group website: http://genev.unige.ch/en/users/Emi-Nagoshi/unit

Selected Publications:

  • Bou Dib P., Gnägi B., Daly F., Sabado V., Tas D., Glauser DA., Meister P., and Nagoshi E. (2014). A Conserved Role for p48 Homologs in Protecting Dopaminergic Neurons from Oxidative Stress. PLoS Genet. 10(10):e1004718.
  • Beuchle D., Jaumouillé E., and Nagoshi, E. (2012). The nuclear receptor unfulfilled is required for free-running clocks in Drosophila pacemaker neurons. Curr. Biol. 22(13):1221-1227.
  • Nagoshi, E., Sugino, K., Kula, E., Okazaki, E., Tachibana, T., Nelson, S., and Rosbash, M. (2010). Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nat. Neurosci. 13(1): 60-68.

Contact:
Department of Genetics and Evolution, Sciences III
Quai Ernest-Ansermet 30
Email: Emi (dot) Nagoshi (at) unige (dot) ch