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Group leader: Philippe Millet

Group name: PET and SPECT Quantification

Affiliation: Psychiatry

Research activities:

image We study the binding kinetics of PET and SPECT radioligands in the brain. Experimental protocols are evaluated for various types of receptors (serotoninergic, dopaminergic). From the kinetics obtained, mathematical models are developed to quantify biological parameters such as receptor density and ligand affinity. This development is carried out in rodents with microPET (link here) or with a radiosensitive intracerebral microprobe system (link here ). The main goal is to develop simple and noninvasive quantitative methods which can then be used to study different pathologies in human, or to study the effects of drugs on receptors (i.e. desensibilisation).

Selected Publications:

  • Millet P, Graf C, Moulin M, Ibanez V (2006) SPECT quantification of benzodiazepine receptor concentration using a dual-ligand approach. J Nucl Med 47:783-92.
  • Millet P, Sallanon MM, Petit JM, Charnay Y, Vallet P, Morel C, Cespuglio R, Magistretti PJ, Ibanez V (2004) In vivo measurement of glucose utilization in rats using a beta-microprobe: direct comparison with autoradiography. J Cereb Blood Flow Metab 24:1015-24.
  • Millet P, Graf C, Buck A, Walder B, Ibanez V (2002) Evaluation of the reference tissue models for PET and SPECT benzodiazepine binding parameters. Neuroimage 17:928-42.

Contact:
Service de Neuropsychiatrie
Unité de Neuroimagerie Psychiatrique
Email: Philippe (dot) Millet (at) hcuge (dot) ch