Université de Genève

Neuroscience center

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Group leader: Philippe Millet

Group name: PET and SPECT Quantification

Affiliation: Psychiatry

Research activities:

image The research projects of our group focus on various themes of neuroimaging including: 1- Development of quantitative imaging methods in PET/SPECT for the study of different cerebral neurotransmission systems (kinetic modeling of dopaminergic (D2/3) and serotonergic (5-HT2A) neurotransmission), neuroinflammation using various PET/SPECT TSPO tracers (18kDa Translocator Protein). 2- pPreclinical PET/SPECT applications: study of the mechanism of action of atypical antipsychotics (SNF n¡156829); In vivo study of rodent neuroinflammation with the use of adenoviral vector-mediated protein overexpression and a TSPO deficient mouse model; Study of neuroinflammation in relation to amyloid deposits and behavioral and cognitive alterations in transgenic models of Alzheimer's disease (collaboration: Dr Benjamin Tournier, benjamin.tournier@hcuge.ch). 3- in vitro studies on the post-mortem human brain for the identification and characterization of inflammation with respect to neurodegenerative pathologies. 4- clinical applications, particularly study of neuroinflammatory process in various psychiatric pathologies (project under development) (collaborations: Dr Stergios Tsartsalis, stergios.tsartsalis@hcuge.ch; Dr Benjamin Tournier, benjamin.tournier@hcuge.ch). 5- development of SPECT / PET radioligands in collaboration with the CERMN (Center for Studies and Research on the Medicine of Normandy, Caen, http://cermn.unicaen.fr/) and ANSTO (Australian Nuclear Science and Technology Organization, http://www.ansto.gov.au/ResearchHub/).

Selected Publications:

  • Tsartsalis S., Tournier B.B., Aoun K., Habiby S., Pandolfo D., Dimiziani A., Ginovart N., Millet P. (2017) A single-scan protocol for absolute D2/3 quantification with [123]IBZM SPECT. Neuroimage. 147 : 461-472.
  • Dumas N, Moulin-Sallanon M, Fender P, Tournier BB, Ginovart N, Charnay Y, Millet P (2015) In vivo quantification of 5-HT2A brain receptors in Mdr1a KO rats with 123I-R91150. Molecular Imaging.
  • Millet P., Moulin M., Tournier B., Dumas N., Charnay Y., Ib‡–ez V., Ginovart N. (2012) Quantification of dopamine D2/3 receptors in rat brain using factor analysis corrected [18F] Fallypride images. Neuroimage. 17:928-42.
  • Millet P., Graf C., Moulin M., Ibanez V. (2006) SPECT quantification of benzodiazepine receptor concentration using a dual-ligand approach. J Nucl Med. 47:783-92.
  • Millet P., Sallanon MM., Petit JM., Charnay Y., Vallet P., Morel C., Cespuglio R., Magistretti PJ., Ibanez V. (2004). In vivo measurement of glucose utilization in rats using a beta-microprobe: direct comparison with autoradiography. J Cereb Blood Flow Metab. 24:1015-24.

Département de santé mentale et de psychiatrie
Service de psychiatrie adulte
Email: Philippe (dot) Millet (at) hcuge (dot) ch