Université de Genève

Neuroscience center

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Group leader: Jean-Marc Matter

Group name: Neurogenesis

Affiliation: Sciences

Research activities:

image Linking the regulation of gene expression to ontogenesis remains a major issue in developmental neurobiology. We are interested in defining how the interplay between regulatory factors and key transcriptional targets coordinates the complex processes of neuron specification and morphogenesis of the retina. Although retina development relies on the whole on regulatory proteins widely expressed in the developing nervous system, Atoh7 expression is a specific feature of retina ontogenesis. We focus on the regulation and function of Atoh7 as a key determinant of the retina cell fate and as an important regulator of neuronal patterning. We ask how Atoh7 interconnects a cell fate decision with the genetic pathways that regulate cell cycle exit, cell polarity and cell migration.

Selected Publications:

  • Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F. (2008) Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature, 455, 114-118.
  • Matter-Sadzinski L, Puzianowska-Kuznicka M, Hernandez J, Ballivet M, and Matter J.-M. (2005) A bHLH transcriptional network regulating the specification of retinal ganglion cells. Development, 132, 3907-3921
  • Skowronska-Krawczyk, D., Chiodini, F., Ebeling, M., Alliod, C., Kundzewicz, A., Castro, D., Ballivet, M., Guillemot, F., Matter-Sadzinski, L., and Matter, J.-M. (2009) Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis. Development, 136, 3767-3777.

Contact:
Département de Biochimie
Faculté des Sciences
Email: Jean-Marc (dot) Matter (at) unige (dot) ch