Université de Genève

Neuroscience center

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Group leader: Denis Jabaudon

Group name: Developmental neurobiology and plasticity

Affiliation: Medical Sciences

Research activities:

My research interests are in studying the genetic mechanisms that control cortical neuron circuit assembly during development. Specifically, work in my laboratory is aimed at identifying the gene expression programs that enable distinct subtypes of thalamic and neocortical neurons to assemble into modality-specific circuits, and understanding how sensory experience regulates these differentiation programs during development. The approaches we use to address these questions include in vivo genetic gain-and-loss of function approaches, including in utero electroporation; structural and functional analysis of transgenic mice, and electrophysiology. We have recently demonstrated functionally critical reciprocal interactions between developmental gene expression programs and circuit formation, and trust that in the long term these processes could be used to direct the recruitment of developmental mechanisms to repair abnormal or lesioned circuits.

Group website: http://www.unige.ch/medecine/neuf/en/research/denis-jabaudon3/research/

Selected Publications:

  • Frangeul L, Pouchelon G, Telley L, Lefort S, Luscher C, Jabaudon D. A cross-modal genetic framework for the development and plasticity of sensory pathways. Nature 2016, 538: 96-98 doi: 10.1038/nature19770.
  • Telley L, Govindan S, Stevant I, Prados J, Dermitzakis E, Nef S, Dayer A, Jabaudon D. Sequential transcriptional waves direct early neuronal differentiation in the mouse neocortex. Science 2016 ; 351(6280):1443-6. doi: 10.1126/science.aad8361.
  • Pouchelon G, Golding B, Bellone C, Gambino F, LŸscher C, Holtmaat A, Jabaudon D. Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons. Nature 2014; 511(7510): 471-474. doi: 10.1038/nature13390.

Contact:
University Medical Center
Département des neurosciences fondamentales
Email: denis (dot) jabaudon (at) unige (dot) ch