Universit� de Gen�ve

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Group leader: Alexandre Dayer

Group name: Psychiatry and Developmental Neuroplasticity

Affiliation: University Hospital

Research activities:

image Neurodevelopmental abnormalities are thought to play a key role in the etiology of major psychiatric disorders such as bipolar disorder and schizophrenia. Among these developmental abnormalities, defects in the migration and differentiation of GABAergic interneurons have been suggested. In the laboratory we aim to study psychiatric-relevant molecular factors that control the migration and differentiation of cortical GABAergic interneurons during the embyronic period and the early postnatal period. For this purpose, we use mutant mice for genes implicated in cortical development as well as transgenic mice expressing GFP in cortical GABAergic interneurons. We apply a broad array of techniques including in vitro migration essays and confocal live imaging to directly monitor interneuron migration in cortical slices.

Selected Publications:

  • Riccio O, Potter G, Walzer C, Vallet P, Szabo G, Vutskits L, Kiss JZ, Dayer AG. Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. Mol Psychiatry, 2009, Mar;14(3):280.290
  • Dayer AG, Jenny B, Potter G, Sauvain MO, Szab G, Vutskits L, Gascon E, Kiss JZ Recruiting new neurons from the subventricular zone to the postnatal cortex: an organotypic slice culture model. European Journal of Neuroscience, 2008, Mar;27:1051-60.
  • Cameron, HA and Dayer AG. New interneurons in the adult cortex: small, sparse but significant? Biol Psychiatry 2007; dec 6.

Geneva University Hospital
Email: Alexandre (dot) Dayer (at) unige (dot) ch